cancer pain
Conditions
Interventions
Group 1:Lactulose + Bifidobacterium triple live capsule
Group 2:Polyethylene glycol electrolyte powder
Sponsors
Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Aged 18-80 years old; (2) diagnosed as a malignant tumor by histopathological or cytological examination; (3) The patient has pain with NRS score = 4 points and needs to be treated with opioids; (4) Survival time of patients is expected to be more than 3 months; (5) Subjects voluntarily joined the study and signed informed consent. His or her compliance is good and intend to follow up.
Exclusion criteria
Exclusion criteria: (1) Probiotics or prebiotics are used within 4 weeks; (2) Patients use antibiotics with infectious diseases; (3) The patient is participating in other clinical trials, or the combined medication is forbidden, or the drug cannot be stopped during the study; (4) The investigator believes that the patient's history may affect the patient's ability to comply with the test or interfere with the assessment of the safety of the test drug; (5) Other circumstances considered unsuitable by the investigator; (6) With serious heart, kidney, liver and other important organ diseases; (7) With history of functional constipation (8) With intestinal obstruction or related gastrointestinal diseases that cause defecation difficulty; (9) Received opioid therapy in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| defecation frequency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life; | — |
Countries
China
Contacts
Public ContactJiang Bin
Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed