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Clinical study for different drugs combined with ropivacaine for local infiltration analgesia after laparotomy: a prospective randomized double-blind controlled trial

Clinical study for different drugs combined with ropivacaine for local infiltration analgesia after laparotomy: a prospective randomized double-blind controlled trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800019209
Enrollment
Unknown
Registered
2018-10-31
Start date
2018-11-15
Completion date
Unknown
Last updated
2020-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laparotomy

Interventions

Group R:0.75% ropivacaine 20ml
Group RN:Nalbuphine 10mg+0.75% ropivacaine (20ml)
Group RK:Ketorolac 25mg+ 0.75% ropivacaine (20ml)

Sponsors

The First Affiliated Hospital of Henan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 60 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria were: American Anesthetist (ASA) I or III, BMI 18-24 kg/m2, aged 35-60 years, for patients undergoing open surgery.

Exclusion criteria

Exclusion criteria: History of open surgery, wound site infection, coagulation dysfunction, local anesthesia drug allergy, long-term opioid or antiemetic drug use, pregnant women, patients with central neuropathy, patients with liver and kidney dysfunction, patients with mental disorders, overweight patients (BMI > 30 kg / m2), hypotension, etc. And patients refused to participate.

Design outcomes

Primary

MeasureTime frame
analgesia duration;

Secondary

MeasureTime frame
NRS score; total morphine equivalent consumption;the additional rescue analgesia rates;

Countries

China

Contacts

Public ContactZheng Xiao-Zhen

The First Affiliated Hospital of Henan University

573870613@qq.com+86 13938632449

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 16, 2026