sepsis and septic shock
Conditions
Interventions
Aminophylline group: Receive a infusion of Aminophylline 3mg/kg within 30 min and followed by an infusion at 0.4mg/kg/h for 5 days
control group:Based on standard of care
Sponsors
the First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Conform to the Society of Critical Care Medicine (SCCM)/the European Society of Intensive Care Medicine (ESICM) of sepsis criteria for diagnosis of sepsis-3: 1. Suspected or confirmed infection: clinical doctors diagnose; 2. An acute change in total SOFA scores 2 points consequent to the infection. The baseline SOFA score can be assumed to be zero in patients not known to have preexisting organ dysfunction.
Exclusion criteria
Exclusion criteria: 1. younger than 18 years old or older than 70 years old; 2. pregnancy or lactation; 3. New York heart association class 4 of congestive heart failure,acute myocardic infarction,malignant arrhythmia, non-infectious cardiogenic shock, uncontrolled acute blood loss; 4. solid organ or bone marrow transplant recipients;Rounding out the top; 5. received cardiopulmonary resuscitation (CPR) within 72 hours; 6. evidence of leukopenia, neutrophil count (ANC) absolutely < 0.5 x 10^9/L; 7. received high-dose corticosteroids before evaluation, namely received methylprednisolone 500 mg/day, use more than 3 days; 8. HIV positive; 9. blood/lymphatic system tumor without remission; 10. don't gain consent or authorization; 11. take part in screening for other exploratory clinical trials?within 6 months; 12. systolic blood pressure is greater than 140 mmHg or diastolic blood pressure is greater than 90 mmHg; 13. uremia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation;Length of hospitalization in ICU;Number of organ failure;Infection site;Pathogenic bacterium;Oxygenation index;Vital signs;Urine volume;APACHE II score;SOFA score;Biochemical index;PCT;Routine blood examination;blood coagulation tests;C-reactive protein; | — |
Countries
China
Contacts
Public ContactTongwen Sun
the First Affiliated Hospital of Zhengzhou University
Outcome results
None listed