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Impact of artificial pneumothorax on perioperative coagulation and fibrinolysis in patients esophagectomy for squamous cell carcinoma

Impact of artificial pneumothorax on perioperative coagulation and fibrinolysis in patients esophagectomy for squamous cell carcinoma

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800019004
Enrollment
Unknown
Registered
2018-10-20
Start date
2017-11-01
Completion date
Unknown
Last updated
2018-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer

Interventions

Experience group:artificial pneumothorax
control group:one-lung ventilation

Sponsors

Third Affiliated Hospital of Army Medical University (Field Surgery Institute)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
46 Years to 76 Years

Inclusion criteria

Inclusion criteria: (1) preoperative diagnosis of esophageal cancer and the fitting line of surgical treatment of patients.All patients with preoperative gastroscopy and pathological diagnosis of esophageal squamous cell carcinomas, and pathologic TNM stage does not exceed T3a; (2) the preoperative CT confirmed the feasibility of chest esophageal cancer effect a radical cure; (3) preoperative cardiopulmonary function, kidney function, blood coagulation function in patients with no obvious abnormalities; (4) in patients with preoperative two weeks without using drugs affect the function of blood coagulation (such as: history of heparin, antiplatelet agents (aspirin and dipyridamole), coumarin, coumarin, warfarin), a new oral anticoagulants (especially the new development of public oral X a direct factor and II a inhibitors). (5) No acute infection, no chronic inflammation, no metabolism or endocrine disease; (6) The American society of anesthesiologists (ASA) grade II - level III.

Exclusion criteria

Exclusion criteria: (1) patients don't agree to be included in the object of study; (2) the preoperative gastroscopy pathology TNM stage than T3a, or according to the imaging result evaluation thoracoscope was unable to complete esophageal cancer radical surgery; (3) preoperative cardiopulmonary function merge, liver and kidney function, blood coagulation function obviously abnormal; (4) preoperative two weeks used drugs affect blood coagulation function (such as: heparin, antiplatelet agents (aspirin and dipyridamole), coumarin, coumarin, warfarin), a new oral anticoagulants (especially the new development of public oral X a direct factor and II a inhibitors)); (5) preoperative complicating acute infection, chronic inflammation, metabolism and endocrine diseases; (6) ASA sizing does not conform to the person.

Design outcomes

Primary

MeasureTime frame
TEG;Blood gas analysis;t-PA;PAI;

Countries

China

Contacts

Public ContactYan Hong

Third Affiliated Hospital of Army Medical University (Field Surgery Institute)

cqyanhong@163.com+86 13638319969

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 16, 2026