Cirrhosis
Conditions
Interventions
1:Huangqi Decoction
2:huangqi decoction and entecavir
3:placebo and entecavir
Sponsors
Shuguang Hospital affiliated Shanghai University of TCM
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Previous history of hepatitis B or HBsAg positive is greater than 6 months; aged 18-65 years old male and female; clinically diagnosed as hepatitis B patients with cirrhosis: imaging is consistent with liver cirrhosis characteristics (ultrasound B showed liver shrinkage, surface unevenness, substance Uneven echo, nodular, widened in the portal vein or splenic vein, etc.; Liver transient ultrasound examination, liver hardness value = 14 kPa. Child-Pugh classification of liver function grade B, total score 7-9, ALT<2×ULN, TBIL<2×ULN (standard upper limit); viral load detection: HBeAg positive, HBV-DNA<1×10^5 copies/ml, HBeAg-negative, HBV-DNA<1×10^4 copies/ml; may have portal hypertension, such as mild esophageal varices, small amount of ascites, hepatic encephalopathy, but no upper gastrointestinal bleeding; tha subject or his guardian agree Participate in randomized controlled trials and sign informed consent.
Exclusion criteria
Exclusion criteria: Alcoholic drug-induced hereditary, immunological, other viral or non-viral chronic hepatitis patients; diagnosed as chronic hepatitis B with severe or severe hepatitis; cirrhosis with Child-Pugh score 100µg/L; patients with severe cardiovascular, pulmonary, renal, endocrine, neurological and hematological diseases; immunodeficient patients: such as HIV infection or near Take immunosuppressive agents or glucocorticoids (such as cyclosporin, azathioprine, adrenocortical hormone), or chemotherapeutic agents (such as cyclophosphamide, methotrexate, cancer chemotherapy) and radiotherapy within 3 months; Organ transplantation (such as liver, kidney, lung, heart) or bone marrow transplantation and stem cell transplantation; pregnant women, pregnant or lactating women; known to be allergic or intolerant to any component of the test drug; mental illness, alcohol abuse history, Drug or other substance abusers; those who have participated in any drug trial in the past 1 month. Other circumstances that the investigator believes are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| liver function;kidney function;blood test;urine test; | — |
Countries
China
Contacts
Public ContactZhang Hua
Shuguang Hospital affiliated with Shanghai University of TCM
Outcome results
None listed