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Mechanisms of iron homeostasis in the pathogenesis of aortic dissection / aneurysm

Mechanisms of iron homeostasis in the pathogenesis of aortic dissection / aneurysm

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800018970
Enrollment
Unknown
Registered
2018-10-19
Start date
2018-01-01
Completion date
Unknown
Last updated
2018-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aortic dissection/aneurysm

Interventions

aortic diseases group:no
normal group:no

Sponsors

Renmin Hospital of Wuhan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. patients with initial aortic dissection and aortic aneurysm; 2. with detailed clinical data and basic personal information, complete imaging data and support for diagnosis; 3. The patient did not receive a large amount of fluid therapy or blood transfusion treatment outside the hospital when he was admitted to the hospital; 4. blood system test is basically normal: neutrophils = 2 * 10^9/L, white blood cells = 4 * 10^9/L, hemoglobin = 100g/L. Liver and kidney function is basically normal: serum albumin 40~55g/L; alanine aminotransferase (ALT) 5-40 U/L; aspartate aminotransferase (AST) 8-40U/L; total bilirubin (STB) 1.71-17.1 µmol/L; direct bilirubin (CB) 1.71-7µmol/L (1-4 mg/L); blood urea 3.2-7.0 mmol/L; creatinine clearance > 60 ml/ml.

Exclusion criteria

Exclusion criteria: 1. has a familial aortic disease; 2. has been diagnosed or highly suspicious: connective tissue disease, Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, Tuner syndrome, hereditary vascular disease; 3. traumatic aortic dissection, infectious aortitis (syphilitic arteritis, tuberculous arteritis); 4. autoimmune disease-related aortitis: systemic lupus erythematosus, giant cell arteritis, Takayasu arteritis, Behet disease; 5. shock; obvious organ failure.

Design outcomes

Primary

MeasureTime frame
Fe;TIBC;TF;TS;sTFR;FER;Fe content in tissues;TF in tissues;TFRC in tissues;

Secondary

MeasureTime frame
Hb;PT;APTT;

Countries

China

Contacts

Public ContactZhiwei Wang

Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University

wangzhiwei@whu.edu.cn+86 13995628899

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026