chronic renal failure
Conditions
Interventions
Group 1:using no ACEI/ARB drugs
Group 2:using losartan 100mg
Group 3:using losartan 200mg
Sponsors
the Aflliliate Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) 120 cases of peritoneal dialysis at least one month were selected,regardless of gender and primary disease,whose age between 18 and 70.No additional cinicl trails were conducted within 3 months; (2) Residual renal function was assessed above 5mL/min/1.73m^2. Formula RRF= (renal urea clearance + renal creatinine clearance) /2; Renal urea clearance rate = (concentration of urine BUN/concentration of serum BUN) *24h urine volume /1440ml;Renal creatinine clearance = (urine creatinine concentration/blood creatinine concentration) *24h urine volume /1440ml; (3) 1.5% or 2.5% peritoneal dialysis fluid were used 3 to 5 times per day; (4) Blood pressure should be above 110/60mmHg with or without antihypertensive drugs; (5) If ACEI or ARB drugs were uesd recently,those should be discontinued for one month before enrollment; (6) Volunteer for this clinical trial study and sign informed consent.
Exclusion criteria
Exclusion criteria: With systemic infectious disease, recurrent peritonitis, congestive heart failure, serious heart valve disease, malignant hypertension,major vascular disease, recent six months had a myocardial infarction and cerebral infarction,chronic liver disease, malignant tumor,mental disorders, bilateral renal artery stenosis,allergic to ARB/ACEI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| residual renal function;ECT-GFR;urine volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine;blood urea; | — |
Countries
China
Contacts
Public ContactJiang Chunming
the Aflliliate Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed