Venous thromboembolism
Conditions
Interventions
Control group:Physical prophylaxis Lower limb thrombosis
Tranexamic acid group:1g of intravenous tranexamic acid before incision, maintained at 15mg/kg during operation
Tranexamic acid + rivaroxaban group:1g of tranexamic acid before incision, maintained at 15mg/kg during operation, and rivaroxaban 8 hours after operation
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Adults older than 18 years of age; 2. Patients diagnosed with intertrochanteric fractures who require surgery; 3. Anesthesia risk rating scores ASA 1-3; 4. Willing to join the study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with PE or DVT; 2. Patients with obvious liver disease (such as hepatitis B, hepatitis C, acute hepatitis, chronic active hepatitis, cirrhosis); 3. Creatinine clearance 180 mmHg or diastolic blood pressure > 110 mmHg; 6. may not be contraceptive measures may be pregnant, pregnant or lactating women; 7. need to apply CYP3A4 potent inhibitors; 8. acquired color vision Patients with disorders; 9. patients with thrombin; 10. patients with history of convulsions; 11. patients with atrial fibrillation with thrombophilia, patients after stent implantation, patients with cardiac pacemakers, etc.; 12. long-term oral antiplatelet drugs Patient; 13. long-term use of metformin patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bleeding volume during operation;bleeding volume after operation;Hemoglobin;D-dimer;Hematocrit;Prothrombin time;Activated partial thromboplastin time;Dual-leg vein ultrasound; | — |
Countries
China
Contacts
Public ContactChen Yunzhen
Qilu Hospital of Shandong University
Outcome results
None listed