ischemic cardiomyopathy
Conditions
Interventions
Group 2:Benazepril hydrochloride
Sponsors
The First affiliated hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Chronic coronary heart disease; 2. NYHA(heart failure) grade ii-iv or angina pectoris grade CCS III or IV or symptomatic compliance; 3. The ejection fraction is below 50%; 4. Stable medication for at least one month; 5. Coronary angioplasty with or without internal stents; 6. Aged> 18 years old; 7. to be able to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe valvular heart disease; 2. Severe congenital heart disease; 3. Hyperthyroidism, anemia and other hyperdynamic heart disease; 4. Combined with pulmonary heart disease; 5. Hypertrophic obstructive cardiomyopathy; 6. Patients with a history of cardiogenic shock within 2 weeks(SBP<90mmHg or DBP<60mmHg at enrollment); 7. Liver insufficiency (defined as ALT or total bilirubin 3 times than the normal upper limit); 8. Renal insufficiency (eGFR < 30 ml/min/1.73m2); 9. Pregnant and lactating women, women of childbearing age who cannot strictly control contraception during treatment; 10. Participated in other clinical researchers within 3 months; 11. Taking drugs prohibited by the study; 12. Persons without legal capacity or limited legal capacity. 14. Any condition that the investigator deems inappropriate to participate in the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiac death;Rehospitalization due to heart failure; | — |
Secondary
| Measure | Time frame |
|---|---|
| all-cause mortality;revascularization;cardiogenic shock;Nonfatal myocardial infarction;stroke;Changes in heart function according NYHA score;Changes in objective physical signs :such as EF and cardio-thoracic proportion);6-minute walk test;Changes of serum BNP, nt-probnp concentrations;Hospital admission rates due to non-heart failure;Patient compliance; | — |
Countries
China
Contacts
Public ContactLing LI
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed