AECOPD
Conditions
Interventions
Group 1:Methylprednisone was used 40mg/ day for 5 days, and methyl prednisone was discontinued after expiration
Group 2:Methylprednisone 40mg/ day, continuous use for 5 days, gradually reduce after maturity, reduce 10mg every 2 days, and stop using methyl prednisone at 10 days
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. patients aged 40-70 years; 2. patients with AECOPD (patients complained of symptoms of sudden changes (baseline dyspnea, cough, and/or sputum) more than the daily variation range of patients with COPD (always check lung function: with bronchial relaxation, FEV1 / FVC < 0.70)); 3. The subjects should be volunteers and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. patients with AECOPD in a critical condition, in which the auxiliary breathing muscles participate in respiratory movement, chest and abdomen contradictory breathing, cyanosis, and invasive mechanical ventilation are required; 2. patients with concomitant signs of lower limb edema, right heart failure and hemodynamic instability; 3. patients with merge spiritual changes; 4. patients with malignant tumors or other serious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical symptoms;pulmonary function test;blood routine examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood gas analysis;Serum inflammatory markers;FeNO;phlegma;Echocardiography;CT Scan of the Lungs;Rating scales;Medication; | — |
Countries
China
Contacts
Public ContactLiu Huiguo
Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed