cerebral small vessel disease
Conditions
Interventions
treatment group:western treatment and tonifying kidney and removing blood stasis chinese medicine
control group:western treatment
Sponsors
Shanghai 6th People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. clinical manifestations: asymptomatic lacunar infarction, CMB and partial leukoaraiosis, various lacunar syndrome and vascular cognitive dysfunction; imaging findings: lacunar infarction (LI) or lacunar (lacune) Or white matter lesions (WML) or perivascular space enlargement or cerebral microbleeds (CMB); 2. no major cerebral vascular disease or intracranial tumor by skull MRI; 3. aged from 40 to 80 years old; 4. MoCA scale < 26 points; 5. subjects volunteered to participate in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. There are other cerebral small vessel diseases such as amyloid angiopathy; other hereditary disease-related small vessel diseases (such as CADSIL, FABRY disease, etc.), inflammation and immune-mediated VCSV and vasculitis, other small venous collagen diseases History of vascular disease; severe arrhythmia such as atrial fibrillation, stroke caused by Parkinson's disease, macrovascular disease, cardiogenic stroke, exclude other diseases that affect intelligence; 2. severe liver and kidney dysfunction; 3. allergic constitution Or those who are allergic to multiple drugs; 4. those with other serious diseases, such as malignant tumors, severe malnutrition, mental disorders, etc.; 5. MoCA scale=26; 6. excluded from macroangiopathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure and blood pressure variability;MoCA;PWV/ABI; | — |
Secondary
| Measure | Time frame |
|---|---|
| TC;TG;LDL-c;HDL-c;FPG;2hPG;HbA1c;D-Dimer; | — |
Countries
China
Contacts
Public ContactWang Tian-zhan
Shanghai 6th People's Hospital
Outcome results
None listed