Parkinson's disease with foot dystonia
Conditions
Interventions
1:Botulinum toxin injection
2:Placebo injection
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of medicine
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged 30-80 years; 2) Accorded with the diagnosis of primary Parkinson's disease, maintained the stability of anti-Parkinson disease drugs for at least 3 months, and ensured the stability of drugs during the follow-up; 3) Unilateral or bilateral foot dystonia with symptoms lasting at least 1 hour per day, causing pain or affecting walking, and no response to baclofen treatment; 4) Evaluate the degree of foot spasm and pain in patients with PD at the ON and OFF stage to exclude the dopaminergic drug related foot dystonia; 5) Electromyography showed spasmodic potential to further confirm foot dystonia; 6) Never been treated with botulinum toxin in the past.
Exclusion criteria
Exclusion criteria: 1) Patients who could not walk independently; 2) Patients with resistance to botulinum toxin; 3) Patients with a history of rheumatoid arthritis; 4) Patients with psychiatric symptoms or dementia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gait; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of spasm;Severity of pain;Quality of life; | — |
Countries
China
Contacts
Public ContactWu Yiwen
Ruijin Hospital, Shanghai Jiao Tong University School of medicine
Outcome results
None listed