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Clinical efficacy and safety of drug-eluting transcatheter arterial chemoembolization (DEB-TACE) combined with Antiangiogenic drugs in the treatment of liver cancer

Clinical efficacy and safety of drug-eluting transcatheter arterial chemoembolization (DEB-TACE) combined with Apatinib in the treatment of liver cancer

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800018855
Enrollment
Unknown
Registered
2018-10-14
Start date
2018-10-11
Completion date
Unknown
Last updated
2019-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular Carcinoma

Interventions

Case series: DEB-TACE

Sponsors

The First Affiliated Hospital,College of Medicine,Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) aged 18-75 years male and female; 2) hepatocellular carcinoma was diagnosed by histopathological or clinical diagnosis (refer to the 2017 edition of the diagnostic and therapeutic guidelines for primary liver cancer); 3) unresectable advanced HCC; 4) the expected survival period is more than 3 months; 5) good liver function: child-pugh A or B (< = 7); 6) blood routine HB was greater than or equal to 90g/L;PLT greater than 50 x 109/L (no blood transfusion or drug therapy was corrected within 14 days before screening); 7) ECOG scores 0-2; 8) understand and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1) patients with distant metastasis of tumor; 2) patients with obvious arteriovenous fistula;3) liver transplant recipients; 4) has suffered from or is currently developing other malignant tumors; Above level 5) ? myocardial ischemia and myocardial infarction, high blood pressure and the drug treatment can't will to normal range (contraction >140mmHg, diastolic >90mmHg); 6) patients with a history of gastrointestinal bleeding or obvious bleeding tendency within 6 months; 7) urine routine showed that urine protein was greater than ++ or 24-hour urinary protein quantification was confirmed; 8) pregnant or lactating women; 9) patients who have participated in other experimental drugs or instruments within 4 weeks.

Design outcomes

Primary

MeasureTime frame
CR+PR;TTP (time-to-progression);

Countries

China

Contacts

Public ContactBao-quan Wang

The First Affiliated Hospital, College of Medicine, Zhejiang University

916825483@qq.com+86 15906602716

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026