Alzheimer disease
Conditions
Interventions
Cases:deep brain stimulation
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Aged 65-75 years; 2) Body weight 40-90 kg; 3) Diagnosis of probable AD according to the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria; 4) Score between 20 and 26 on the Mini Mental State Examinationsubject have a CDR of 1.0; 5) The memory loss was at least 12 months, with a progressive worsening trend; 6) There were no obvious signs of nervous system examination; 7) If the patient is on AD medication, the regimen must remain stable for the first 3 months of enrollment and for the entire study period; 8) Subjects should have stable and reliable caregivers; 9) The subjects were primary school and above; 10) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Other causes of dementia; 2. Have suffered from nervous system diseases; 3. psychotic; 4. MRI examination during screening showed significant focal lesions; 5. Cannot tolerate MRI or has MRI contraindications; 6. Abnormal laboratory indicators; 7. Uncontrolled high blood pressure; 8. Have unstable or serious heart, lung, liver, kidney, hematopoietic system diseases; 9. Alcohol or drug abuse; 10. Other clinical trials were conducted within 30 days before the screening visit; 11. The researchers considered it impossible for the subject to complete the study; 12. Surgical contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function; | — |
Countries
China
Contacts
Public ContactDou wanchen
Peking Union Medical College Hospital
Outcome results
None listed