Aortic arch pathologies
Conditions
Interventions
Experimental group:total arch replacement and stented elephant trunk implantation with the new surgical strategy
Controlled group:total arch replacement and stented elephant trunk implantation with traditional technique
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. patients with aortic arch pathologies who require total arch replacement and stented elephant trunk implantation.
Exclusion criteria
Exclusion criteria: 1) preoperative serum cretinine level = 200µmmol/L, or anuria/oliguria or receiving renal replacement therapy; 2) preoperative ALT or AST = 2×ULN; 3) serious gastrointestinal ischemic dysfunction; 4) serious lower extremities ischemic dysfunction; 5) preoperative intubation state; 6) aortic inflammatory diseases including Bechet disease, Takayasu's arteritis; 7) prior cerebral infarction with serious sequelae; 8) pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of major adverse events incluing mortality, stroke, paraplegia, acute kidney injury necessitating dialysis, myocardial infarction and low cardiac output syndrom within 30 days post operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| total medical costs during hospitalization; | — |
Countries
China
Contacts
Public ContactSun Xiaogang
Fuwai Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed