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Association of PDE4D gene and ALOX5AP gene with intracranial artery stenosis: a multicenter hospital-based case control study

Intracranial vessel screening and Genetic Susceptibility study in Siblings of patients with Symptomatic Stenosis of Intracranial Artery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800018798
Enrollment
Unknown
Registered
2018-10-10
Start date
2018-11-01
Completion date
Unknown
Last updated
2018-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

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Interventions

group of participants with symptomatic stenosis of intracranial artery:PDE4D gene and ALOX5AP gene
group of participants with asymptomatic stenosis of intracranial artery:PDE4D gene and ALOX5AP gene
group of participants without stenosis of intracranial artery:PDE4D gene and ALOX5AP gene

Sponsors

Huashan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: For probands: 1. Aged 40-75 years; 2. Diagnosis of acute cerebral infarction; 3. Confirmed intracranial artery stenosis of more than 50 percent by CTA, MRA TOF or DSA ; 4. Should be recruited at least 90 days after stroke onset ; 5. Willingness of At least one sibling to participate in this study; 6. Willingness of the participant and all his/her guradians to provide written informed consent. For siblings: 1. 18 years of age or older; 2. At least one sibling diagnosed with cerebral infarction.

Exclusion criteria

Exclusion criteria: For probands: 1. Concurrent life-threatening disease including heart failure, respiratory failure, acute or chronic hepatic dysfunction, acute or chronic renal function, tumors and hematological disease; 2. History of psychiatric disorders; 3. Pregnancy; 4. Participating in other clinical studies concurrently. For siblings: 1. Concurrent life-threatening disease including heart failure, respiratory failure, acute or chronic hepatic dysfunction, acute or chronic renal function, tumors and hematological disease; 2. Allergy to contrast agent or inability to tolerant with head CTA ; 3. History of psychiatric disorders; 4. Pregnancy; 5. Participating in other clinical studies concurrently; 6. Inabililty to contact; 7. Unwillingness to provide written informed consent.

Design outcomes

Primary

MeasureTime frame
frequency distribution of PDE4D genotypes and alleles;frequency distribution of ALOX5AP genotypes and alleles;—

Secondary

MeasureTime frame
degree of intracranial arterial stenosis;location of intracranial arterial stenosis;—

Countries

China

Contacts

Public ContactYi Dong

Huashan Hospital, Fudan University

drdongyi@yeah.net+86 13916665674

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026