acute myocardial infarction
Conditions
Interventions
MSCs?::MSCs
EECP+MSCs???:EECP+MSCs
Sponsors
Jiangmen Central Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) aged 30 ~ 80 years old male and female; (2) for the first time, the anterior wall acute st-elevation myocardial infarction (STEMI) patients; (3) within 14 days of 24 hours and not the emergency opening infarction related coronary artery; (4) left ventricular overall low systolic function (LVEF 50% or less); (5) willing to stem cell therapy and follow-up examination within the given time; (6) have signed approved by the ethics committee of stem cell transplantation therapy of informed consent.
Exclusion criteria
Exclusion criteria: (1) the AMI complicated with cardiac shock (KILLIP4 level); (2) atrial fibrillation to warfarin anticoagulation or anticoagulant therapy at high risk of bleeding; (3) serious malignant arrhythmia (polymorphic ventricular tachycardia and ventricular fibrillation, ventricular flutter, height or III degree atrioventricular block need to implant a pacemaker); (4) the huge AMI complicated with left ventricular aneurysm requiring surgical operation; (5) with mechanical complications of acute myocardial infarction (including: ventricular septal perforation, papillary muscle rupture, etc.); (5) the AMI has line of stem cell therapy; (6) in chronic obstructive pulmonary disease (copd) (bronchial asthma, chronic bronchitis, emphysema, cor pulmonale); (7) of acute infectious diseases; (8) Hepatitis b, hepatitis c or AIDS patients; (9) blood system diseases, such as thrombocytopenia, severe anemia, leukemia, etc; (10) serious kidney disease, creatinine clearance 133 umol/L (11) liver function is abnormal obviously, GPT (ALT) > 3 times the upper limit of normal value; (12) has a history of cerebral hemorrhage patients; (13) in patients with malignant tumor; (14) cognitive dysfunction and dementia patients, patients with serious mental illness; (15) of patients with severe physical disabilities affect regular follow-up; (16) with some other serious uncontrolled system disease; (17) to prepare or have the pregnancy women patients; (18) have a PCI contraindications: such as digestive tract, intracranial and other parts of the patients at high risk of bleeding, or contrast allergy;Or intolerance to dual antiplatelet therapy for at least 1 year; (19) EECP contraindications to patients, to severe aortic regurgitation in full;Sandwich or aneurysm;Significant pulmonary hypertension; (20) unable or unwilling to sign the informed consent of the patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LVEF;LVDd; | — |
Countries
China
Contacts
Public ContactWeidong Gao
Jiangmen Central Hospital
Outcome results
None listed