Paediatric hepatic tumour
Conditions
Interventions
Group A – Very Low Risk HB A1:No further treatment
Group A – Very Low Risk HB A2:2 cycles cisplatin
Group B - Low Risk HB Patients B1:2 cycles cisplatin vs 4 cycles cisplatin
Group B - Low Risk HB Patients B2:resected after 2 cycles cispltin and 2 cycles cisplatin following
Group C - Intermediat e Risk HB Patients:SIOPEL-3HR vs C5VD vs CDDP-M
Group D - High Risk HB Patients D1:Arm A-CD
Group D - High Risk HB Patients D2:CD alternating with CE
Group D - High Risk HB Patients D3:CD alternating with VI
Group E - Resected HCC Patients E1:No further treatment
Group E - Resected HCC Patients E2:denovo HCC OLADO
Group F - Not Resected HCC Patients E1:PALDO+S vs PALDO + S/GEMOX + S
Sponsors
Guangzhou Woman and Children's Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Clinical diagnosis of HB* and histologically defined diagnosis of HB or HCC. Histological confirmation of HB is required except in emergency situations where: 1. the patient meets all other eligibility criteria, but is too ill to undergo a biopsy safely, the patient may be enrolled without a biopsy; 2. there is anatomic or mechanical compromise of critical organ function by tumour(e.g., respiratory distress/failure, abdominal compartment syndrome, urinary obstruction, etc.); 3. Uncorrectable coagulopathy 4. Aged =30 years; 5. Written informed consent for trial entry.
Exclusion criteria
Exclusion criteria: 1. Any previous chemotherapy or currently receiving anti-cancer agents; 2. Recurrent disease; 3. Previously received a solid organ transplant; other than orthotopic liver transplantation (OLT); 4. Uncontrolled infection; 5. Unable to follow or comply with the protocol for any reason; 6. Second malignancy; 7. Pregnant or breastfeeding women.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Response in HCC;Best Response;Surgical resectability;Adherence to surgical guidelines; | — |
Primary
| Measure | Time frame |
|---|---|
| EFS;OS;FFS;Toxicity; | — |
Countries
China
Contacts
Public ContactYan Zou
Guangzhou Woman and Children's Medical Center
Outcome results
None listed