Brain damage
Conditions
Interventions
Group 2:In the DK group, dexmedetomidine (0.2-0.7) was administered with g/kg/h and ketamine (0.3-0.5) mg/kg/h intravenous pump
Group 1:The use of dexmedetomidine same as DF group, with efflux g/kg/h after fentanyl (0.5~1.0).
Sponsors
Department of Intensive Medcine, Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. undergoing elective patients with heart valve replacement operation under CPB, ASA class I-III; Heart function class I-III; 2. Body mass index of 18.5 ~ 23.9 kg / ?;Subjects were assessed on the preoperative simple mental status examination scale at 27 points on > and expected CPB time at > for 30 minutes.
Exclusion criteria
Exclusion criteria: 1. With important organ diseases such as liver and kidney, history of cerebrovascular and neuropsychiatric diseases, and brain trauma surgery; 2. with history of cerebrovascular accident in patients with severe hypertension, hypotension or bradycardia; Those with increased intracranial pressure, such as intracranial aneurysm and intracranial tumor, etc.; 3. With increased intraocular pressure; 4. Patients with hyperthyroidism and adrenal pheochromocytoma; 5. Patients with epilepsy and schizophrenia; 6. Patients with sinus bradycardia or hypotension; 7. Patients with difficulty in communication (such as hearing or speech communication); 8. The patient who refused to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| S-100ß protein, neuron specific enolase; | — |
Countries
China
Contacts
Public ContactZhao Wenjing
Department of Intensive Medcine, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed