Surgical treatment for degenerative joint disease
Conditions
Interventions
Group A:TXA: IV 1g+ IA 0g
Group B:TXA: IV 1g+ IA 1g
Group C:TXA: IV 1g+ IA 2g
Group D:TXA: IV 1g+ IA 3g
Sponsors
Changzheng Hospital Affiliated to Naval Military University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. patients with unilateral degenerative osteoarthritis of the knee according to diagnostic criteria for knee osteoarthritis (ICD-10 M17 .901); 2. normal preoperative hemoglobin (Hb) levels, normal coagulation function and renal function; 3. normal deep veins in the legs on color Doppler echography; and 4. stable concurrent chronic diseases, if any.
Exclusion criteria
Exclusion criteria: 1. patients with anemia; 2. patients with abnormal coagulation function; 3. patients with liver or kidney dysfunction; 4. pa-tients with a history of bleeding disorders; 5. patients with a history of deep vein thrombosis (DVT); 6. patients with hyper-coagulability or risk factors of thrombosis (e.g., atrial fibrillation, coronary stenting, tumors, or long-term use of hormones); and 7. patients with a known history of TXA hypersensitivity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drainage volume;Hemoglobin;thromboembolic event;Transfusion unit; | — |
Secondary
| Measure | Time frame |
|---|---|
| Healing of incision; | — |
Countries
China
Contacts
Public ContactQirong Qian
Nantong Sixth People's Hospital, Changzheng Hospital Affiliated to Naval Military University
Outcome results
None listed