rectal cancer
Conditions
Interventions
SIB-IMRT group:SIB-IMRT technology for neoadjuvant synchronous chemoradiotherapy
R-IMRT group:Conventional segmented radiotherapy for neoadjuvant concurrent chemoradiotherapy
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. histopathological confirmation of rectal adenocarcinoma; 2. aged 18-75 years; 3. The survival period is estimated to be over 6 months; 4. resectable tumor distal border located within 10cm from anal verge; 5. pre-treatment tumor staging cT3-4 or N+ without distant metastatic disease; 6. without any chemotherapy history or abdominal and pelvic radiotherapy history; 7. the white blood cell count=3.5x109/L, the hemoglobin count=11g/dl; the platelet count=100x10^9/L; 8. adequate liver function and renal function (bilirubin and AST or ALT; creatinine must be=1.5 times upper normal limit); 9. all patients must consent to be in the study.
Exclusion criteria
Exclusion criteria: Except adenocarcinoma, the malignant rectal tumor such as sarcoma, lymphoma, carcinoid were excluded. Patients must not have other previously cancer and previously receive chemotherapyradiotherapy to the pelvis, or have contraindications to the CRT. 1. patients with distant metastasis; 2. systemic infections are not yet controlled; 3. chronic wasting diseases; 4. in pregnancy and lactation; 5. in chronic hormone or systemic immunotherapy; ) combined with severe hypertension, liver and kidney dysfunction, and abnormal bone marrow function; 6. History of radiotherapy and chemotherapy or other anti-tumor treatment (including immunotherapy) for other malignant tumors, combined with severe heart, liver, kidney and lung diseases; hereditary syndrome; 7. recurrent rectal cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The tumor regression grading(TRG);T downstaging rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sphincter preservation rate;toxicity effects; | — |
Countries
China
Contacts
Public ContactYong Zhang
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed