lymphoma
Conditions
Interventions
A:rhTPO 15000U injectioninjection at Day -2\-1\and day 2-7, total 8 doses.
B:rhTPO 15000U injection everyday for 8 doses after chemotherapy
Sponsors
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with lymphoma confirmed by histopathology and who was relapsed or progress after first-line treatment; 2. Aged 18 to 65 years; 3. ECOG performance status of 0,1or2; 4. At least one measurable lesion is present; 5. Life expectancy of >3 months; 6. Adequate hepatic function: ALT =3G/L, absolute neutrophil count >=1.5G/L, hemoglobin>=100g/L, and platelet count >=75G/L; 7. LVEF>=45% by echocardiography; 8. Cardiac function was classified as grade I, II; 9. Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Lymphoma invades the central nervous system; 2. History of severe allergic or anaphylactic reactions to any drugs including the protocol; 3. Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol or interpretation of results, including significant cardiovascular disease, uncontrolled diabetes mellitus, pulmonary disease or severe hepatic and renal dysfunction; 4. serious infections; 5. History of other malignancy; 6. Mental disorder; 7. All patients of reproductive potential refuse to use adequate methods of contraception during the treatment period; 8. Patients were not suitable for this study concluded by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet minimum; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thrombocytopenia duration;Platelet transfusion volume;incidence of level III thrombocytopenia;incidence of level IV thrombocytopenia;Cost associated with thrombocytopenia; | — |
Countries
China
Contacts
Public ContactLiling Zhang
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed