Aortic dissection
Conditions
Interventions
Group 1:del Nido cardioplegia
Group 2:St. Thomas cardioplegia
Sponsors
Xijing Hospital of The Fourth Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of acute type A aortic dissection or intramural hematoma requires aortic arch replacement; 2. No surgical contraindications, including severe liver, kidney, heart, lung insufficiency, or a history of coma; 3. Age 18-75 years; 4. Obtain informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Preoperative use of inotropic pharmacologic support; 3. Preoperative use of mechanical circulatory support; 4. Preoperative coronary malperfusion; 5. Patients with serious heart disease (such as congestive heart failure, untreated or worsened arrhythmias, ventricular arrhythmias); 6. Patients with myocardial infarction occurred within 3 months before enrollment; 7. Preoperative complications included severe cerebral and visceral malperfusion, leading to stroke, coma, renal failure, gastrointestinal bleeding; 8. Preoperative cardiac troponin I (cTnI) greater than 0.3 ng/ml; 9. unwilling to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Troponin I (cTnI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Vasoactive-inotropic Score (VIS);rate of return to spontaneous rhythm ;Debrillation;Changes of left ventricular ejection fraction after operation;CPB time;cross-clamp time;circulatory arrest time;total volume of cardioplegia;number of cardioplegia doses administered;blood transfusion volume;length of intensive care unit;mechanical ventilation time;Postoperative hospital stay;Postoperative complications;In-hospital mortality;30 day postoperative mortality; | — |
Countries
China
Contacts
Public ContactDUAN WEIXUN
Xijing Hospital of The Fourth Military Medical University
Outcome results
None listed