stroke
Conditions
Interventions
Group 1:neural mobilization and comprehensive rehabilitation for affected upper extremity
Group 2:comprehensive rehabilitation for affected upper extremity
Sponsors
Department of rehabilitation medicine,Guangdong Second Provincial General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The first onset of stroke patients aged 50 to 70 years old, identified unilateral basal ganglion infarction by CT or MRI examination; 2. The patients' motor functions(Fugl-Meyer integral score) of affected sides were comparable at the baseline; 3. the patients be able to understand and follow instructions, recognize the body parts and keep sustained attention for more than five minutes.
Exclusion criteria
Exclusion criteria: 1. Multiple embolic infarctions; 2. Dementia, comprehensible aphasia, or complete aphasia; 3. The cerebellar or extrapyramidal syndrome contracture of joints and stiff limbs which influence on physical activity; 4. Other neuromuscular diseases which impair motor function; 5. With metal implanted electronic device embedded(cardiac pacemaker) and other limited conditions; 6. Depressive state (Hamilton depression scale score>15); 7. Severe claustrophobic syndrome; 8. Unilateral spatial neglectclock drawing test(+); 9. Patient or the family who refused the present treatment plans.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer motor assessment scale, FMA, FMA-UE of affected upper limb;modified Barthel index, MBI;DTI imaging: fractional anisotropy(FA);DTI imaging: mean diffusive (MD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of upper limb motor function: Range of motion(Shoulder flexion and elbow extension);fMRI imaging analyse of active regions: 1. primary sensori-motor cortex, SMC; 2. premotor cortex, PMC; 3. supplementary motor area, SMA; 4. inferior parietal lobules, IPL; 5. prefrontal cortex, PFC; 6. cingulated motor area, CMA; 7. cerebellum, CRB;laterality index (fMRI), LI: LI (M1) = (C-I)/(C+I); LI (SMC) = (C-I)/(C+I); LI (CRB) = (C-I)/(C+I); | — |
Countries
China
Contacts
Public ContactYingping Jiang
Guangdong Second Provincial General Hospital
Outcome results
None listed