colorectal cancer
Conditions
Interventions
Case Series:DEBIRI+FOLFIRI
Sponsors
Guangdong General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-75 years male and female, patients with colorectal liver metastases were diagnosed by histology or EASL imaging diagnostic criteria; 2. ECOG physical status score 30%; platelet count = 50×10^9/L; neutrophil count> 1.0X10^9/L; normal coagulation function; Cr<2mg/dl; AST/ALT, Bil, TP, ALB all within the normal range; 7. patients should follow the protocol requirements and sign informed consent; if not, families or statutory guardian should sign informed consent.
Exclusion criteria
Exclusion criteria: 1. liver cirrhosis, ascites, portal hypertension, major portal vein tumor thrombi; 2. extrahepatic metastases; 3. suffered from other malignant tumors in the past five years; 4. hypertensive crisis or hypertensive encephalopathy; 5. severe cardiovascular and cerebrovascular diseases, including cerebrovascular accident and myocardial infarction (6 months before enrollment), uncontrolled hypertension after proper medication; unstable angina pectoris; congestive heart-failure (NYHA2-4); arrhythmia requires medication; 6. suffered from or physical examination indicated that central nervous system disease, inculding primary brain tumor, uncontrollable epilepsy after standard treatment, brain metastases and a history of stroke; 7. severe uncontrolled systemic complications such as infection or diabetes; 8. participated in other drug or device clinical trials within 4 weeks; 9. allergic to any of the drugs in the study; 10. allergic to the nonionic contrast medium; 11. pregnant or lactating woman; 12. fertile woman has not used or rejected effective non-hormonal birth control, including intrauterine contraceptive ring, barrier method combined with spermicidal gel or sterilization surgery; or man who is likely to give birth; 13. the complication or social environment that can cause the subject to fail to follow the study plan or even endanger the patient's safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;HPFS;OS; | — |
Countries
China
Contacts
Public ContactXu Rongde
Guangdong General Hospital
Outcome results
None listed