systemic inflammatory response during cardiopulmonary bypass
Conditions
Interventions
Case series:Without any intervention
Sponsors
Institutional Review Board of Children's Hospital Affiliated Chongqing Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. The study group consisted of 15 children with open heart surgery under cardiopulmonary bypass, aged 1 to 6 years old; 2. In the control group, 15 children underwent open-thoracic PDA ligation under non-extracorporeal circulation, aged 1 to 6 years; 3. Preoperative ASA classification is in grades I to II; 4. Family members and children voluntarily participate in the study program and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) The child or family member refuses to participate in the research project; (2) History of recent upper respiratory tract infections; (3) Being receiving immunosuppressive therapy or gene therapy; (4) severe cardiac insufficiency, ASA grade III and above; (5) Other important organs are incomplete.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atg-5 gene expression;LC-3 protein expression;Autophagy morphology;Neutrophil apoptosis rate; | — |
Countries
China
Contacts
Public ContactWang Shouyong
Institutional Review Board of Children's Hospital Affiliated Chongqing Medical University
Outcome results
None listed