Non-small Cell Lung Cancer
Conditions
Interventions
Case series:apatinib mesylate combined with IP chemotherapy
Sponsors
Affiliated Cancer Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years male and female; 2. Histologically or cytologically confirmed,Second-line patient with small cell lung cancer; 3. At least one extracranial measurable lesion according to the evaluation criteria of solid tumor efficacy (RECIST 1.1), CT scan Long diameter of tumor=10mm; 4. ECOG score 0-2; 5. The main organ function is normal, and meet the following standards: (1) The standard of blood routine examination should be consistent: HB=80 g/L, ANC=1.5×10^9/L, PLT=80×10^9/L; (2) Biochemical tests should meet the following criteria: BIL50ml/min; 6. Estimated survival time=3 mouths; 7. Patients voluntarily entered the study and signed informed consent form (ICF); 8. Fertile woman must perform a pregnancy test (serum or urine) 7 days before screened, or voluntarily adopt proper methods of contraception during the observation period; For men, surgery should be sterilized or agreed to use appropriate methods of contraception during observation.
Exclusion criteria
Exclusion criteria: 1. pregnant or lactating women; 2. People with high blood pressure who cannot be reduced to the normal range by antihypertensive medication (systolic blood pressure >140 mmHg, diastolic blood pressure >90 mmHg); Arrhythmia with grade I or higher myocardial ischemia or myocardial infarction (including QTc interphase more than 440 MS) and I level cardiac insufficiency; 3. Have a variety of factors that affect the oral and absorption of drugs (such as can not swallow, after gastrointestinal resection, chronic diarrhea and intestinal obstruction, etc.); 4. Abnormal coagulation (PTorPT-INR>1.5ULN or APTT>1.5 ULN), bleeding tendency(such as: active gastrointestinal ulcer lesions) or receiving coagulation therapy; 5. There are clear gastrointestinal or other organ bleeding concerned (such as: local active ulcer lesions, fecal occult blood (++)), history of gastrointestinal bleeding within 6 months; 6. long nonunion or incomplete healing of the fracture; 7. urine protein positive patients (urine protein test 2+ or above, or 24 hours urine protein quantitative >1.0g); 8. patients with mental substance abuse history who are unable to quit or have mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| size of the lesions; | — |
Countries
China
Contacts
Public ContactYan Wang
Affiliated Cancer Hospital of Harbin Medical University
Outcome results
None listed