Chronic kidney disease
Conditions
Interventions
Control group:Standardized treatment is based on existing guidelines / treatment routinely, but no Chinese medicine rehabilitation program was used.
Low compliance group of comprehensive rehabilitation program of Chinese medicine :Standardized treatment is based on existing guidelines / treatment routinely , while using TCM rehabilitation program
High compliance group of comprehensive rehabilitation program of Chinese medicine :Standardized treatment is based on existing guidelines / treatment routinely , while using TCM rehabilitation program
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 80 years; 2) Comply with the diagnostic criteria for chronic kidney disease, GFR 15-ml/min/1.73m2; 3) The fluctuation range is less than 30% in the first 3 months; 4) All patients are required to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Dialysis is needed immediately; 2. being treated with hormone, non steroidal anti-inflammatory drugs or immunosuppressive agents; 3. Renal vascular disease; myocardial infarction or cerebrovascular accident; 4. Interstitial diseases and obstructive nephropathy; 5. Pregnant or lactating patients; 6. Those who are unable to cooperate, such as psychotic patients; 7. Combined with active malignancies, decompensated cirrhosis, hematopoietic system and other severe primary diseases; 8. Combined with infectious diseases; 9. Severe arrhythmia, severe heart failure, NYHA grade III and above; 10. Patients taking part in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eGFR decline slope of Renal function progress; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change slope of urine protein;Routine blood test;liver function;renal function;Electrolyte;blood fat;electrocardiogram;Renal B-ultrasound;Stool routine + Occult Blood;Time to End-stage renal disease(Maintenance dialysis or kidney transplantation or eGFR progression to <10 ml/min/1.73m2);Time to the occurrence of a significant decrease in renal function(eGFR decreased by 50% or absolute value decreased by 25 ml/min/1.73m2);Time to the composite clinical outcome((either end-point event occurring or eGFR decreasing by 50% or absolute value decreasing by 25 ml/min/1.73 m2));Incidence of cardiovascular events (myocardial infarction, acute coronary syndrome, chronic heart failure, severe arrhythmia);All-cause mortality and cardiovascular event related mortality;All-cause hospitalization rate;Effectiveness evaluation of chronic disease management;Progress in urinary protein;Risk factor stabilization time;Risk factor control compliance rate;Dosage and typers of drugs associated with risk factors; | — |
Countries
China
Contacts
Public ContactLiu Xusheng?Mao Wei
Guangzhou University of Chinese Medicine
Outcome results
None listed