cervical cancer
Conditions
Interventions
Case series:Endostar (recombinant human endostain)combined with concurrent radiochemotherapy
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. patients aged 18-75 years; 2. Patients with histologically proven cervical cancer, initial treatment or local recurrence after surgery; 3. patients with cervical cancer in clinical Stage IIB- IVA according to the staging standard of FIGO, and cannot be surgery; 4. patients with a ECOG score 0-2 points; 5. Tumor that can be measured (according to the RECIST 1.1 standard); 6. patients with an expected survival period >6 months; 7. Blood, liver and kidney function well, meeting laboratory test resultspatients with white blood cell count >3.5×10^9/L, neutrophil count >1.5×10^9/L, blood platelet count=100×10^9/L, a hemoglobin level =9 g/dL, liver function indexes1.5 times of the upper limit of the normal value, creatinine renal clearance rate =50 ml/min; 8. patients understand the study and have signed an informed consent. 9. Conditions for follow-up.
Exclusion criteria
Exclusion criteria: 1. patients with other primary malignant tumors; 2. Contraindications for radiotherapy and chemotherapy, including severe infection or other complications such as myocardial infarction, severe heart arrhythmia, severe cerebrovascular disease, psychosis and uncontrolled diabetes; 3. A woman who is pregnant, lactating, or who is fertile but does not use contraception; 4. patients who have received EGFR targeted therapy and immunological therapy; 5. patients who being tested for other drugs; 6. The researchers determined that other causes could not be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;DCR; | — |
Countries
China
Contacts
Public ContactZhou Juying
The First Affiliated Hospital of Soochow University
Outcome results
None listed