non small cell lung cancer with brain metastasis
Conditions
Interventions
Two groups:whole-brain radiotherapy plus sequential versus simultaneous integrated boost
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Pathologically diagnosed patients with non-small cell lung cancer; 2. Signing radiotherapy consent before treatment, no contraindications for radiotherapy; 3. Imaging CT or MRI or PET-CT confirmed intracranial metastases lesions =10; 4. Aged 18-80 years old, ECOG 0-2 points or Kanofsky score >60 points, expected to survive more than 1 month; 5. The maximum diameter of intracranial metastatic lesions less than 5 cm; 6. Extracranial lesions receive systemic treatment as planned; 7. Can cooperate with the completion of the MMSE questionnaire content.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women, women of childbearing age are not contraceptive; 2. Patients with a history of other active malignancies other than non small cell lung cancer brain metastases before enrollment; 3. Being undergoing other clinical trials; 4. Patients with severe co-morbidity, including myocardial infarction, severe arrhythmia, severe cerebrovascular disease, mental illness, etc.; 5. No condition of regular follow-up and poor compliance; 6. Use targeted drugs; 7. Cannot accept MRI or CT examin; 8. Allergic to contrast agents; 9. Cannot meet prescription dose requirements; 10. with leptomeningeal involvement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination; | — |
Countries
China
Contacts
Public ContactDaiyuan MA
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed