pulmonary disease
Conditions
Interventions
Group A: PCIA + Flurbiprofen axetil 50mg
Group B:PCIA+ dezocine 5mg
Group C:PCIA + flurbiprofen axetil 50mg+ dezocine 5mg
Group D:PCIA + flurbiprofen axetil 25mg+ dezocine 2.5mg
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 70 years; 2. Male: weight =45kg, female: weight =42kg; 3. Patients undergoing pulmonary lobectomy surgery; 4. ASA scores I-II grade; 5. Known numeric rating scales (NRS); 6. Known how to use patient-controlled intravenous analgesia (PCIA); 7. Had essential complete materials such as clinical staging of lung cancer and medications situation; 8. Willing to participant after reading and signing an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Time for smoking cessation <2 weeks; 2. Patients undergoing other pulmonary operations rather than lobectomy; 3. Patient with allergies to opioids, non-steroidal anti-inflammatory drugs (NSAIDs); 4. Patients were pregnant or breastfeeding women; 5. Patients with preoperative severe mental illness; 6. Patients with preoperative gastrointestinal or blood system disease; 7. Patients with grade 3 hypertension; 8. Patients underwent cardiac ischemia; 9. Patients received preoperative radiotherapy or neoadjuvant chemotherapy; 10. The investigator judges that the patient is not suitable for inclusion in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The numeric rating scales (NRS);the total consumption of sufentanil after operations;incidence of experimental drug-related adverse effects: nausea, vomiting, dizziness, fatigue, drowsiness, pruritus, abdominal distention, bloating, constipation, euphoria, respiratory depression and indigestion; | — |
Secondary
| Measure | Time frame |
|---|---|
| the analgesia cost;chest tube duration;length of hospital stay;gastrointestinal exhaust time;the serum level of interleukin-1ß (IL-1ß), IL-6, IL-8, IL-2, tumor necrosis factor-a (TNF-a), C-reactive protein (CRP)?prostaglandin E2 (PGE2)?5-hydroxytryptamine (5-HT);dezocine additional time,times,additional quantity;postoperative time to get out of bed; | — |
Countries
China
Contacts
Public ContactLunxu Liu
West China Hospital, Sichuan University
Outcome results
None listed