Obstructive sleep apnea hypopnea syndrome
Conditions
Interventions
Case group:None
Control group:None
Sponsors
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
4 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Case group: Padiatric OSAHS confirmed by standard polysomnography (PSG) (AHI>5 times/hour); Control group: children who underwent general anesthesia in the hospital (congenital diseases such as mouth cyst, cleft palate and preauricular fistula without infection) 2. aged 4 to 12 years old; 3. no obvious dietary preferences; 4. agree to participate in the study; 5. Parents of children can answer the questionaire.
Exclusion criteria
Exclusion criteria: 1. Special diet: gluten-free, casein diet, or special carbohydrate diet; 2. systemic disease (i.e., pulmonary, hepatic, renal, cardiovascular, gastrointestinal, or neurological disease), oral disease (i.e., dental caries or periodontal disease), any treatment for adenoid hypertrophy (i.e., tonsillectomy and adenoidectomy, corticosteroids, or leukotriene antagonists); 3. genetic/craniofacial syndromes, parents with obvious snoring or diagnosed OSA, receipt of any medicationsantibiotics or drugs used to regulate intestinal flora (i.e., prebiotics, synbiotics, or probiotics]during the previous month, and any active infections (i.e., bacteria, fungi, or viruses). Subjects who had pets at home (a known source of bacteria) were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| behavior ability; | — |
Secondary
| Measure | Time frame |
|---|---|
| fecal microflora;Adenoid microflora;Oral microflora;Serum metabolites;Urine metabolites;Inflammatory factors;Immune parameters; | — |
Countries
China
Contacts
Public ContactHuajun Xu
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Outcome results
None listed