Liver Cancer
Conditions
Interventions
Gold Standard:The diagnose will be confirmed using AASLD practice guideline for chronic Hepatitis B
of 
to 
cancer
Sponsors
Beijing Epidial Medical Diagnosis Technology Co., Ltd.
Eligibility
Sex/Gender
Male
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: For HCC patient inclusion criteria include confirmed diagnosis of HCC by EASL-EORTC guidelines and confirmed hepatitis B diagnosis for HepB patients using AASLD practice guidelines. Healthy controls will be matched to the patient group for age, sex, smoking and alcohol consumption. Whole-blood specimens will be ideally collected before start of standard therapy.
Exclusion criteria
Exclusion criteria: For HCC a strict exclusion criterion is cirrhosis, any other known inflammatory disease (bacterial or viral infection with the exception of hepatitis B or C, diabetes, asthma, autoimmune disease, active thyroid disease) which could alter T cells and monocytes characteristics as well as other cancers. For HepB patient exclusion criteria in addition to the above will be diagnosis of HCC or any other cancer. For healthy controls, exclusion criteria include any known inflammatory or infectious disease including HepB and HepC and any diagnosis of chronic disease, cancer, medications use, or drugs of abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Methylation level of the target genes; | — |
Countries
China
Contacts
Public ContactNing Li
Beijing Youan Hospital, Capital Medical School, Beijing, China
Outcome results
None listed