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Recombinant human TWEAK in the treatment of postoperative wounds of pigmented nevi

TWEAK/Fn14 signaling modulates keratinocytes bidirectionally and emerges as therapeutic target under inflammatory microenvironments

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800018396
Enrollment
Unknown
Registered
2018-09-15
Start date
2018-09-17
Completion date
Unknown
Last updated
2018-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin trauma

Interventions

Group 1:Erythromycin ointment + RhTWEAK gel
Group 2:Erythromycin ointment + matrix gel
Group 3:Erythromycin ointment + recombinant human epidermal growth factor gel
Group 4:Erythromycin ointment

Sponsors

The Second Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Male or female patients aged 18 to 75 years old; (2) There are at least 4 pigmented nevi located at the face, chest or back or limb symmetry, which are suitable for laser treatment; (3) The patients sign the informed consent form before this clinical trial.

Exclusion criteria

Exclusion criteria: (1) The patients suffer from other skin diseases such as eczema and psoriasis or mental illness; (2) The patients have suspected or indeed a history of alcohol or drug abuse; (3) The patients have other diseases such as malignant tumors, vascular abnormalities, immunodeficiency, diabetes, severe kidney disease, etc., which may cause delayed wound healing; (4) The patients are using drugs that affect wound healing such as chemotherapy and immunosuppressive agents; (5) The pregnant women and lactating women; (6) The patients have allergic history (allergic to two or more drugs, food and pollen) are allergic to the pharmaceutical ingredients (carbomer 940, triethanolamine, p-hydroxybenzylamine ethyl ester and ethanol); (7) The patients are suffering from severe or uncontrolled local or systemic acute or chronic infections; (8) The patients are believed by the investigators not suitable for participating in this trial.

Design outcomes

Primary

MeasureTime frame
Wound healing time;

Secondary

MeasureTime frame
Beauty effect;

Countries

China

Contacts

Public ContactYumin Xia

The Second Affiliated Hospital of Xi'an Jiaotong University

xiayumin1202@163.com+86 15619371713

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026