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A clinical trial and application of pulsed radiofrequency treatment of genicular nerves for muscle atrophy in knee osteoarthritis

A clinical trial and application of pulsed radiofrequency treatment of genicular nerves for muscle atrophy in knee osteoarthritis

Status
Active, not recruiting
Phases
Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800018378
Enrollment
Unknown
Registered
2018-09-14
Start date
2018-09-15
Completion date
Unknown
Last updated
2018-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Group 2:pulsed radiofrequency treatment
Group 1:Knee pain points lidocaine and diprospan injection

Sponsors

Huadong Hospital Affiliated To Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. All subjects meet diagnostic criteria derived from the American rheumatism association (ACR), aged from 18 to 75 years old male or female: 2. Repeated pain in knee for almost a month; 3. X ray film suggested osteophyte has formed; 4. Fulfil one of the following conditions: morning stiffness within 30 min, joints have rubs in motion, aged from 18 to 75 years. And satisfy: (1) Repeated pain in knee for almost a month; (2) X ray film suggested osteophyte has formed; (3) Without receiving drug therapy within two weeks; 5. ruled out the subjects with active gastrointestinal tract, gastrointestinal ulcers in a year, cardiac insufficiency, kidney, liver disease or blood coagulation dysfunction and diagnosised with infectious arthritis, gout or acute Knee Osteoarthritis injured; 6. excluding the subjects with NSAID allergy history; 7. Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Do not meet the above-mentioned inclusion standards; 2. Subjects did not follow the scheduled treatment, unable to determine the efficacy or the data is not complete, and these factors will have an effect on the evaluation of treatment effect; 3. Subjects who are receiving other treatments, and the treatments will affect the index observation of study effects; 4. Subjects participated in other drug clinical trials within four weeks; 5. Subjects accompanied with life-threatening primary disease derived from cardio-cerebrovascular, liver, kidney and hematopoietic system and mental patients, etc.; 6. Pregnant and nursing women; 7. Subjects, with poor compliance for the research procedure, cannot finish the research plan, including dysphasia, infectious diseases and other medical history

Design outcomes

Primary

MeasureTime frame
Visual Analogue Scale;WOMAC scale;isokinetic force;

Countries

China

Contacts

Public ContactYongjun Zheng

Huadong Hospital Affiliated To Fudan University

zhengyongjyn1971@126.com+86 18116267895

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026