the remifentanil-reduced postoperative hyperalgesia.
Conditions
Interventions
Group C:a single bolus of saline given 30min before the end of the surgery
Group LD:a single bolus of 0.2ug/kg dexmedetomidine given 30min before the end of the surgery
Group HD:a single bolus of 0.5ug/kg dexmedetomidine given 30min before the end of the surgery
Sponsors
Sun Yat-Sen University Cancer Center
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. ASA physical status I or II; 2. Patients aged 20~75 years; 3. Patients undergoing thyroidectom1.
Exclusion criteria
Exclusion criteria: 1. A history of anaesthetic allergy; 2. Mental or neurological disease; 3. Liver or renal dysfunction; 4. BMI > 30kg/m2; 5. Pregnant women; 6. A history of acute or chronic painor undergoing pain treatment; 7. Drugs or alcohol abuse; 8. Cardiovascular disease; 9. Arhythmia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mechanical pain threshold on the peri-incisional area 30min after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| the other mechanical pain threshold on the peri-incisional area or the non-dominant Forearm;Postoperative pain intensity (NRS);the incidence of moderate or severe pain (NRS>4);Total consumption of analgesics 48hr after surgery;time to extubation;length of stay; | — |
Countries
China
Contacts
Public ContactLonghui Cao
Sun Yat-Sen University Cancer Center
Outcome results
None listed