Malignant ascites caused by ovarian cancer
Conditions
Interventions
Group 1:irinotecan single drug chemotherapy
Group 2:irinotecan iv chemotherapy plus endocytosis iv therapy
Group 3:Irinotecan iv chemotherapy plus endor peritoneal peritoneal perfusion therapy
Group 4:Irinotecan iv chemotherapy plus endor peritoneal peritoneal perfusion therapy
Sponsors
Liuzhou Worker's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) aged 18 to 75 years; (2) it was diagnosed as ovarian malignant tumor by histopathological/cytological examination, which recurred after initial treatment and was platinum-resistant ovarian cancer with cancerous ascites; (3) score of the eastern United States tumor cooperative group (ECOG) was 0-2; (4) the predicted survival period is not less than 2 months; (5) the main organs such as heart and lung function normally; (6) more than 4 weeks from major surgery; (7) entered the group voluntarily, signed the informed consent, followed well and cooperated with the follow-up
Exclusion criteria
Exclusion criteria: (1) uncontrolled central nervous system metastasis with intracranial hypertension; (2) tendency of bleeding, especially the occurrence of obvious gastrointestinal bleeding within the last 4 weeks, or receiving thrombolytic therapy or anticoagulation therapy; (3) used other research drugs within 30 days, or participated in other clinical studies at the same time; (4) had myocardial infarction within 6 months, or present unstable angina pectoris, cardiac insufficiency, and severe hepatic and renal insufficiency; (5) patients with severe chronic obstructive pulmonary disease and/or respiratory failure, severe intestinal adhesion, and intestinal obstruction; (6) there are serious uncontrolled infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate;Blood CA125;bloodVEFG; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to progression;Time to progression;Quality of life;Functional status score KPS; | — |
Countries
China
Contacts
Public ContactHe Hongying
Liuzhou Worker's Hospital
Outcome results
None listed