fractures of pelvis and acetabulum
Conditions
Interventions
TXA group:10 mg/kg IV, 30 minutes before incision
followed by the same dosage when the operation exceed 3 hours, and 1 g IV in the first 24 hours after operation
control group :normal saline IV, the same as tranexamic acid
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. patients of pelvic fracture; 2. patients of acetabular fracture.
Exclusion criteria
Exclusion criteria: 1. Allergy to tranexamic acid; 2. Tumor fracture; 3. Acute myocardial infarction within 6 months (not included unstable angina pectoris); 4. thrombophilia; 5. cerebral infarction or cerebral hemorrhage within 6 months; 6. Abnormal coagulation function, such as hemophilia; 7. age80 years; 8. Other situations that researchers think not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood loss;blood transfusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin decline;Hematocrit decline;Erythrocyte concentration decline;Thrombus event;wound complications;length of stay;Hospitalization expenses;mortality;readmission rate; | — |
Countries
China
Contacts
Public ContactGuanglin Wang
West China Hospital, Sichuan University
Outcome results
None listed