Uterine endometrial injury
Conditions
Interventions
Case series:MSC exosomes therapy
Sponsors
Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age between 20 and 45 years old; 2. Repeated uterine cavity operation history , the endometrial thickness is less than 6 mm; 3. Repetitive implantation failure or recurrent abortion result from endometrial factors confirmed by the Color Doppler Ultrasound examination; 4. Ineffective estrogen therapy; 5. Irregular menstrual cycle or cycle cancelled because of thin endometrium; 6. Normal liver, heart, and kidney function; 7. Absence of HIV, Hepatitis B or C, syphilis and psychiatric pathology; 8. Serum ß-hCG is negative.
Exclusion criteria
Exclusion criteria: 1. Combined with other reproductive system diseases ingcluding hysteromyoma, adenomyosis, hydrosalpinx or other chronic diseases that incapable for pregnancy; 2. Patients combined with serious heart disease, liver disease, kedney diseases and diabetes are unsuitable for pregnancy; 3. Patients with malignant tumor; 4. Acute urogenital infection; 5. Allergy to G-CSF or contraindication to G-CSF; 6. Participating in other clinical trials in the latest month; 7. There are serious diseases that endanger patients' safety or affect patients' completion of this study; 8. Patients who have not signed the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endometrial thickness;Endometrial receptivity;Endometrial shape; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial blood supply;Menstrual cycle;Clinical pregnancy rate;estrogen; | — |
Countries
China
Contacts
Public ContactZhao Zhenlin
Outcome results
None listed