Pediatric acute respiratory distress syndrome
Conditions
Interventions
Group 1:Conventional therapy
Group 2:Conventional therapy + small dose methylprednisolone
Group 3:Routine treatment + blood purificatio
Normal control (for reference of neuroendocrine immune mechanism but not for treatment):Nil
Sponsors
Fujian Provincial Maternity and Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 14 Years
Inclusion criteria
Inclusion criteria: 1. A known clinical manifestation within 7 days; 2. Respiratory failure that can not be completely explained by exhaustion or fluid overload; 3. New exudative changes in chest imaging are consistent with acute organic lung injury; 4. In non-invasive mechanical ventilation, mask BiPAP or CPAP is not less than 5cmH2O, P/F is not more than 300; 5. In invasive mechanical ventilation, the oxygenation index is more than 4.
Exclusion criteria
Exclusion criteria: 1. Pediatric patients with perinatal related lung disease; 2. Children with primary or secondary immunodeficiency or who are using immunosuppressive agents; 3. Children with congenital heart disease or dysplasia of the respiratory tract or abnormal development of the chest; 4. Children with malignant tumor and chronic kidney disease; 5. Children with active tuberculosis infection; 6. Children with severe malnutrition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of PaO2/FiO2 =300 orOI =4;Mechanical ventilation time;Survival situation;Peripheral blood lymphocyte subgroup;IL-6;IL-10;SP-D;Ang-2;ACTH;cortisol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to live in PICU;Time of hospitalization;Peptic ulcer bleeding in digestive tract;Hyperglycemia;Double infection; | — |
Countries
China
Contacts
Public ContactLin Hai
Pediatric intensive care unit (PICU), Fujian Provincial Maternity and Children's Hospital
Outcome results
None listed