Effect of Low Dose Dexmedetomidine Infusion on Perioperative Stress, Inflammatory Response Progress and Postoperative Intestinal Function in the Patients Undergoing Spine Surgery

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800018127

Enrollment

Unknown

Registered

2018-08-31

Start date

2018-09-01

Completion date

Unknown

Last updated

2018-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spine Surgery

Interventions

the DEX group:Dexmedetomidine

The control group:saline

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients with lumbar spondylolisthesis of selected period; 2. ASA score I to III; 3. Age >18 years old; 4. BMI is 19kg/m2-35kg/m2; 5. The patient is informed and agrees with the partner.

Exclusion criteria

Exclusion criteria: 1. Sinus bradycardia or II degree atrioventricular block; 2. Before the operation, the drug was used for the adrenalin receptor agonist. 3. Language communication barriers; 4. Abnormal liver and kidney function; 5. Intestinal diseases such as ulcerative colitis, crohn's disease and irritable bowel syndrome.

Design outcomes

Primary

Measure	Time frame
intestinal exhaust;	—

Secondary

Measure	Time frame
lipopolysaccharide;tumor necrosis factor–alpha (TNF-a);C-reaetive protein ( CRP);	—

Countries

China

Contacts

Public ContactWang Tianlong

Anesthesiology Department, Xuanwu Hospital of Capital Medical University

w-tl5595@hotmail.com+86 13910525304

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 19, 2026