Hip fracture
Conditions
Interventions
Group A:1g intravenous tranexamic acid in 100ml normal saline at admission and repeated at 3h interval, 1g intravenous tranexamic acid in 100ml normal saline before skin incision and repeated at 3h in
Group B:1g intravenous tranexamic acid in 100ml normal saline at admission and repeated at 3h interval, 100ml intravenous normal saline before skin incision and repeated at 3h interval.
Group C:100ml intravenous normal saline at admission and repeated at 3h interval, 1g intravenous tranexamic acid in 100ml normal saline before skin incision and repeated at 3h interval.
Group D:100ml intravenous normal saline at admission and repeated at 3h interval, 100ml intravenous normal saline before skin incision and repeated at 3h interval.
Sponsors
The Third Hospital of Mianyang
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Consecutive patients with a diagnosis of hip fractures treated at our hospital by any surgical procedure; (2) Aged over 18 years; (3) Signed informed consent from the patient or legal representative.
Exclusion criteria
Exclusion criteria: (1) Allergy or any contraindication for tranexamic acid; (2) Delayed admission beyond 24h; (3) pathological fracture or open fracture; (4) Multiple fractures or trauma; (5) Discontinuation of oral anticoagulants or aspirin less than 1 week; (6) History of acute thromboembolic event (Deep Vein Thrombosis, Pulmonary Embolism, Stroke); (7) Patients at high risk of thrombosis; (8) Coagulopathy (INR > 1.4).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| transfusion rate;transfusion amount;hidden blood loss;total blood loss;Hb level;Hb drop; | — |
Secondary
| Measure | Time frame |
|---|---|
| fibrinolysis index (D-Dimer, FDP);coagulation markers;length of hospital stay;hospitalization costs; | — |
Countries
China
Contacts
Public ContactCong Xiao
The Third Hospital of Mianyang
Outcome results
None listed