chronic obstructive pulmonary disease
Conditions
Interventions
A:the sequence double/single tube
B:the sequence single/double tube
Sponsors
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) aged 40-80 years old; (2) by medical history, physical examination, chest X-ray or CT scan, pulmonary function tests to confirm the diagnosis, in line with "chronic obstructive pulmonary disease diagnosis and treatment guidelines in 2011 Chinese Medical Association Respiratory Diseases will be developed severe diagnostic criteria "in COPD patients :( FEV1 / FVC <70%, FEV1 <50% predicted values); (3) stabilization: no admission within the past month, drug treatment strategies no change; (4) difficulty in breathing as the main symptoms limit daily activities.
Exclusion criteria
Exclusion criteria: (1) X-ray or chest CT examination revealed bullae; (2) Upper airway or maxillofacial injury, postoperative, deformity, can not be used with NIV or mask discomfort; (3) at rest: inhaled oxygen concentration = 0.50, but oxygen saturation SpO2 160 mm Hg or diastolic blood pressure > 100 mm Hg at rest; unstable angina or myocardial infarction in the past 1 month; (5) sinus tachycardia at rest Speed (> 120 beats / min); (6) skeletal muscle or nervous system dysfunction affecting motor function; (7) other respiratory diseases; (5) disagree with the patients participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| excercise time;Maximum inspiratory pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Parasternal EMG;inspiratory time;Minute ventilation;Peripheral oxygen saturation;respiratory rate;heart rate;Noninvasive blood pressure; | — |
Countries
China
Contacts
Public ContactChen Rongchang
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affliated Hospital of Guangzhou Medical University
Outcome results
None listed