anesthesia induction for patients undergoing cardiac valve replacement
Conditions
Interventions
Group 1:Received oxycodone of 0.25mg/kg for anesthesia induction
Group 2:Received sufentanil of 0.5 µg/kg for anesthesia induction
Sponsors
The Third People's Hospital of Chengdu, Southwest Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged = 18 years old; (2) Preoperative echocardiographic diagnosis of moderate to severe single valve lesions, in line with mitral or aortic valve replacement surgery indications; (3) First elective heart valve replacement; (4) No preoperative glucocorticoid and immunosuppressive treatment; (5) Preoperative blood biochemical indicators were normal; (6) Cardiac function Grade II or III; (7) ASA classification II or III.
Exclusion criteria
Exclusion criteria: (1) Patients with preoperative complications of central nervous system disease; (2) Patients with insulin-dependent diabetes mellitus; (3) Patients with abnormal liver, kidney and lung function or uncontrolled hypertension or diabetes; (4) Patients with abnormal coagulation function; (5) Pregnant and lactating women; (6) opioid dependence history; (7) Patients allergic to research drugs and their components.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate;Adverse reactions during anesthesia induction period; | — |
Primary
| Measure | Time frame |
|---|---|
| cerebral state index (CSI) value;Observer Assessment of Sedation (OAAS) scores;Respiratory rate;PaCO2; | — |
Countries
China
Contacts
Public ContactJian Zhang
The Third People's Hospital of Chengdu, Southwest Jiao Tong University
Outcome results
None listed