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ICU-acquired weakness and diaphragmatic dysfunction in mechanically ventilated patients with sepsis: a prospective observational cohort study

ICU-acquired weakness and diaphragmatic dysfunction in mechanically ventilated patients with sepsis: a prospective observational cohort study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800018085
Enrollment
Unknown
Registered
2018-08-29
Start date
2018-09-01
Completion date
Unknown
Last updated
2018-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

Case series:Nil

Sponsors

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Patients diagnosed as sepsis according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3); (2) Patients required invasive mechanical ventilation for at least 5 days.

Exclusion criteria

Exclusion criteria: (1) age less than 18 years; (2) a previously diagnosed neuromuscular disorder; (3) Patients with central or peripheral nervous system injury; (4) impossibility to assess muscular strength in a limb because of amputation or immobilization; (5)antecedents of cognitive disorders that prevented the understanding of simple orders; (6) unwillingness of the patient or proxy to participate in the study.

Design outcomes

Primary

MeasureTime frame
Medical Research Council (MRC) Score;diaphragmatic thickening fraction(DTF);maximum inspiratory pressure(MIP);

Secondary

MeasureTime frame
durations of mechanical ventilation;Intensive care unit length of stay;ICU mortality;

Countries

China

Contacts

Public ContactLu Zhihua

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

hzhza86403393@zju.edu.cn+86 13588706785

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026