obesity associated hypertension
Conditions
Interventions
Group 1:Qing-Gan-Zi-Shen decoction + conventional medicine for hypertension control
Group 2:conventional medicine for hypertension control
Sponsors
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Between 20 and 70 years old; 2. Consistent with the diagnosis of obesity associated hypertension (BP = 140/90mmhg;BMI of 28Kg/m2 and/or waist circumference of 90/85cm (male/female); 3. Consistent with TCM syndrome of hyperactivity of liver fire or Yin deficiency and Yang hyperactivity; 4. One of the following metabolic disorders (fasting glucose 5.6-6.9 mmol/L;2 hours postprandial blood glucose 7.8-11.0mmol/L;Increased serum lipid level margins: TC 4.9-6.19mmol/L, and/or ldl-c 3.0-4.12mmol/L, and/or TG 1.7-2.25mmol/L, and/or hsl-c 420umol/L in men, >320umol/L in women); 5. Voluntarily participate in the test and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Secondary hypertension; 2. Definitely diagnosed diabetes 3. Pregnant and lactating women; 4. Severe life-threatening diseases, such as acute myocardial infarction, stroke, cardiac insufficiency grade IV; 5. There is a contraindications to use two hydrogen pyridine class calcium ion antagonist and angiotensin ? blockers 6. Patients with a history of mental illness or a legal disability; 7. Currently participate in clinical trials of other drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipostatic evaluation:Factors such as adiponectin, resistin, leptin, tumor necrosis factor (TNF), free fatty acids, interleukin 6, transforming growth factor beas, fibrinolytic activator inhibitor 1,;Analysis of clinical metabolic characteristics:Glycometabolism related indicators, lipid metabolism related indicators, uric acid, urinary albumin, liver B - ultrasound;Visceral fat detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anthropometric indicators:Height, weight, waist circumference, hip circumference;Safety index;Safety index: Liver function, renal function, blood cell count and other safety indicators; | — |
Countries
China
Contacts
Public ContactJiang weimin
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed