depression
Conditions
Interventions
A:Pseudo stimulus + placebo
B:Pseudo stimulus + Escitalopram
C:tDCS + placebo
D:tACS + placebo
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-65 years old, male or female; (2) High school and above, with Chinese as a mother tongue; (3) sufficient audiovisual level to complete the necessary examinations for the study; (4) 7 days before enrollment Did not take any psychotropic drugs; (5) 17 items of Hamilton depression rating scale (HAMD-17) score = 17 points; (6) signed informed consent before enrollment.
Exclusion criteria
Exclusion criteria: (1) Those with severe or unstable physical illness within 3 months or those with stroke within 30 days; (2) Abnormal laboratory tests and judged to be clinically meaningful, the investigators believe that it affects the efficacy of the test or affects the safety of the subjects; (3) Pregnant women, lactating women, women of childbearing age who were positive for urine HCG test during screening. Male and female subjects did not take effective contraceptive measures, or planned to receive (grant) within 3 months after the start of the trial; (4) poor compliance; (5) currently meet other diagnostic criteria for major mental disorders; (6) HAMD-17 Project 3 (suicide) = 3 points, or patients with suicide and self-injury risk; (7) Those who participated in any clinical trial within 30 days before the baseline; (8) Patients with contraindications for magnetic resonance imaging; (9) The investigator believes that there are other conditions that are not suitable for participating in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total score of the HAMD-17;The total score of the HAMA;WCST outcome;Stroop Color-Word Test Outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical routine; | — |
Countries
China
Contacts
Public ContactWang Yong
Shanghai Mental Health Center
Outcome results
None listed