Multiple sclerosis
Conditions
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-55 years; (2) MS is diagnosed according to the diagnostic criteria of McDonald (Revised Edition 2010); (3) the course of the disease was 2-10 years; (4) the baseline of the EDSS score was 2-5 points before the treatment; (5) relapse remission has recurred in the past 12 months. (6) secondary progressive type had recurrence within the past 12 months, or the EDSS score increased by 1 points. (7) there were recurrences in primary progression or GAD enhancement in head MRI.
Exclusion criteria
Exclusion criteria: (1) diseases that interfere with clinical assessment, such as disability (not caused by MS); (2) severe depression; (3) pregnant, lactating women or those who are planning to conceive; (4) do not agree to sign the patient's informed consent; (5) relapse within 30 days. (6) antibiotic treatment in the last 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The EDSS increased by 1 points or more in 60 weeks and continued for 12 weeks.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The progression of upper limb functional disability increased by 20% at 60 weeks and continued for 12 weeks.;the ratio of 25 step walking speed of the subjects decreased by 20% and lasted for 12 weeks in 60 week.;Recurrence times;Annual recurrence rate;new lesion in MRI; | — |
Countries
China
Contacts
Public ContactZhou Liu
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed