The dose-response of ropivacaine in cesarean section for patients undergoing cesarean section with metaraminol infusion

ED50 and ED95 of Intrathecal Hyperbaric Ropivacaine for Parturients Undergoing Cesarean section with Prophylactic Infusion of Metaraminol: A Prospective dose-finding Study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800018053

Enrollment

Unknown

Registered

2018-08-28

Start date

2018-09-01

Completion date

Unknown

Last updated

2018-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cesarean section

Interventions

1:0.5mcg/kg/min Prophylactic infusion of hydroxylamine

2:1.0 mcg/kg/min Prophylactic infusion of hydroxylamine

3:1.5 mcg/kg/min Prophylactic infusion of hydroxylamine

4:2.0 mcg/kg/min Prophylactic infusion of hydroxylamine

5:2.5mcg/kg/min Prophylactic infusion of hydroxylamine

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria were healthy parturients with an ASA statue of I or II, single pregnant.

Exclusion criteria

Exclusion criteria: Exclusion criteria were patients with obesity (body mass index, BMI > 35 kg/m2), gestational age < 37 weeks, active labor, early labor, ruptured membranes, history of previous cesarean deliveries, diabetes or gestational diabetes, hypertension or pre-eclampsia, intrauterine growth restriction, placenta previa, significant coexisting maternal disease, any contraindication to spinal or epidural anesthesia such as local infection or bleeding disorders.

Design outcomes

Primary

Measure	Time frame
effective or ineffective anesthesia;	—

Countries

China

Contacts

Public ContactYaohua Shen

Yuhang District Women and Children Care Hospital

13989852772@163.com+86 13989852772

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026