Reversible Cognitive Frailty
Conditions
Interventions
Experimental group 1:Huperzine A, Quercetin
Experimental group 2:Huperzine A
Experimental group 3:Quercetin
Contro group:Placebo
Sponsors
Huadong hospital, Shanghai medical college, Fudan University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Reversible cognitive frailty patient: pre-physical frailty and physical frailty (Fried score 2-5); meanwhile, subjective cognitive decline (Spain SCD-Q score 0-7); 2. Aged 60-90 years; 3. MMSE 27-30; 4. Subjects capable of understanding the protocol, complying with its requirements, and attending study visits.
Exclusion criteria
Exclusion criteria: 1. Co-medication with NSAIDs (longterm medication), Gingko- or other natural extracts, other AchE inhibitors; 2. Disability or handicap; visual or hearing impairments in compatible with performance and/or interpretation of neuropsychological tests; 3. Other primary psychiatric/neurologic disorders,such as AD;severe depression or generalized anxiety; acute infection diseaseacute traumatic brain injuries, stroke(< 3 months), autoimmune disease, multiple organ failure, which could be life-threatening in the short term; 4. Missing informed consent; 5. No readiness to save and refer pseudonym personal data; 6. Any condition disturbing or making MRI and other measures impossible; 7. Known allergy of elements of huperzine A, quercetin or placebo; 8. Alcohol or drug abuse; 9. Participation in any clinical trial < 3 months prior to screening or ongoing other clinical trials; 10. Other situation that researchers considered not suite to be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| subjective cognitive decline questionaire;NIA-AA MCI criterian; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fried physical frailty score;Mini-Mental State Examination;The Clinical Dementia Rating;Mild cognitive impairment;The Alzheimer’s Disease Assessment Scale;Pure-tone threshold;Speech audiometry;The Tinnitus Functional Index;Tinnitus Handicap Inventory;Quality of Life-8;Blood biomarkers test; | — |
Countries
China
Contacts
Public ContactYU ZHUOWEI
Huadong hospital,Shanghai medical college, Fudan University
Outcome results
None listed